| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | ||||
| 2. Jornada | 30.07.2021 | Puebla FC [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 3:1 |  |
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| 3. Jornada | 07.08.2021 | CF América [Sub 20] | - | Puebla FC [Sub 20] | 3:3 | |
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| 5. Jornada | 18.08.2021 | Club Tijuana [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 7. Jornada | 27.08.2021 | Puebla FC [Sub 20] | - | Gallos Blancos [Sub 20] | 0:1 | ||||
| 9. Jornada | 19.09.2021 | Santos Laguna [Sub 20] | - | Puebla FC [Sub 20] | 4:2 | ||||
| 11. Jornada | 28.09.2021 | Atlas Guadalajara [Sub 20] | - | Puebla FC [Sub 20] | 3:3 | ||||
| 12. Jornada | 01.10.2021 | Puebla FC [Sub 20] | - | CF Pachuca [Sub 20] | 1:1 | |
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| 14. Jornada | 19.10.2021 | Puebla FC [Sub 20] | - | Mazatlán FC [Sub 20] | 2:1 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 |
México