| 4. Jornada | 29.08.2021 | Tauro FC | - | Alianza | 0:0 | ||||
| 5. Jornada | 05.09.2021 | Alianza | - | Plaza Amador | 1:0 |  |
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| 6. Jornada | 11.09.2021 | Alianza | - | Atlético Chiriquí | 2:1 | |
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| 8. Jornada | 26.09.2021 | Independiente de La Chorrera | - | Alianza | 0:0 | ||||
| 9. Jornada | 02.10.2021 | San Francisco FC | - | Alianza | 0:1 | ||||
| 12. Jornada | 23.10.2021 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 16. Jornada | 20.11.2021 | Plaza Amador | - | Alianza | 3:1 |
Panamá