| 7. Jornada | 26.02.2022 | Club Tijuana [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 | ||||
| 8. Jornada | 02.03.2022 | Atlas Guadalajara [Sub 20] | - | CF Pachuca [Sub 20] | 0:3 |  |
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| 9. Jornada | 05.03.2022 | Gallos Blancos [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:1 | ||||
| 10. Jornada | 11.03.2022 | FC Juárez [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:0 | ||||
| 11. Jornada | 20.03.2022 | Atlas Guadalajara [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 12. Jornada | 02.04.2022 | Cruz Azul [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:0 | ||||
| 13. Jornada | 07.04.2022 | Atlas Guadalajara [Sub 20] | - | Club Necaxa [Sub 20] | 1:1 | ||||
| 14. Jornada | 14.04.2022 | Atlas Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 | ||||
| 16. Jornada | 24.04.2022 | Deportivo Toluca [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 |
México