| 1. Jornada | 18.04.2021 | Columbus Crew | - | Philadelphia Union | 0:0 | ||||
| 1. Jornada | 25.04.2021 | Philadelphia Union | - | Inter Miami CF | 1:2 | ||||
| 2. Jornada | 02.05.2021 | Philadelphia Union | - | New York City FC | 0:2 | ||||
| 2. Jornada | 08.05.2021 | Chicago Fire | - | Philadelphia Union | 0:2 | ||||
| 2. Jornada | 13.05.2021 | Philadelphia Union | - | New England Revolution | 1:1 | ||||
| 2. Jornada | 16.05.2021 | Philadelphia Union | - | New York RB | 1:0 | ||||
| 2. Jornada | 31.05.2021 | Philadelphia Union | - | Portland Timbers | 3:0 | ||||
| 3. Jornada | 20.06.2021 | Atlanta United FC | - | Philadelphia Union | 2:2 |  |
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| 5. Jornada | 29.08.2021 | D.C. United | - | Philadelphia Union | 3:1 | ||||
| 6. Jornada | 04.09.2021 | Philadelphia Union | - | New England Revolution | 0:1 | |
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| 6. Jornada | 25.09.2021 | Philadelphia Union | - | Atlanta United FC | 1:0 | ||||
| 7. Jornada | 21.10.2021 | Minnesota United FC | - | Philadelphia Union | 3:2 |
Estados Unidos
Italia