| 16. Jornada | 12.02.2022 | NK Osijek II | - | NK Sesvete | 0:3 | ||||
| 17. Jornada | 20.02.2022 | Dinamo Zagreb II | - | NK Osijek II | 2:1 | ||||
| 18. Jornada | 26.02.2022 | NK Osijek II | - | NK Dugopolje | 2:0 |  |
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| 19. Jornada | 05.03.2022 | NK Solin | - | NK Osijek II | 0:0 | ||||
| 20. Jornada | 14.03.2022 | NK Osijek II | - | NK Dubrava | 0:1 | ||||
| 21. Jornada | 20.03.2022 | NK Croatia Zmijavci | - | NK Osijek II | 1:0 | ||||
| 23. Jornada | 09.04.2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Jornada | 15.04.2022 | NK Osijek II | - | HNK Cibalia | 2:1 |  |
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| 25. Jornada | 23.04.2022 | NK Varaždin | - | NK Osijek II | 4:1 | |
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| 26. Jornada | 02.05.2022 | NK Osijek II | - | NK Inter Zaprešić | 1:2 | ||||
| 28. Jornada | 16.05.2022 | NK Osijek II | - | NK Kustošija | 0:1 | |
Croacia