| 3. Jornada | 22.01.2022 | CF Monterrey [Sub 18] | - | Cruz Azul [Sub 18] | 1:0 | ||||
| 4. Jornada | 07.02.2022 | Club León [Sub 18] | - | Cruz Azul [Sub 18] | 1:0 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [Sub 18] | - | Puebla FC [Sub 18] | 2:0 | ||||
| 10. Jornada | 11.03.2022 | Cruz Azul [Sub 18] | - | Pumas UNAM [Sub 18] | 0:2 | ||||
| 12. Jornada | 02.04.2022 | Cruz Azul [Sub 18] | - | Atlas Guadalajara [Sub 18] | 1:1 | ||||
| 13. Jornada | 08.04.2022 | Mazatlán FC [Sub 18] | - | Cruz Azul [Sub 18] | 1:2 | ||||
| 14. Jornada | 16.04.2022 | Cruz Azul [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:0 | ||||
| 15. Jornada | 21.04.2022 | Gallos Blancos [Sub 18] | - | Cruz Azul [Sub 18] | 1:1 | ||||
| 16. Jornada | 24.04.2022 | Cruz Azul [Sub 18] | - | Atlético San Luis [Sub 18] | 2:1 |  |
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| 17. Jornada | 30.04.2022 | CF América [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | |
México