| 1. Jornada | 07.02.2021 | Club Olimpia | - | Libertad | 0:1 |  |
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| 3. Jornada | 16.02.2021 | Libertad | - | Cerro Porteño | 2:1 |  |
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| 8. Jornada | 14.03.2021 | Sol de América | - | Libertad | 0:2 | ||||
| 12. Jornada | 18.04.2021 | Cerro Porteño | - | Libertad | 0:3 | |
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| 13. Jornada | 26.04.2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | |
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| 15. Jornada | 09.05.2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 | ||||
| 16. Jornada | 17.05.2021 | Guaraní | - | Libertad | 1:6 | ||||
| 17. Jornada | 22.05.2021 | Libertad | - | Sol de América | 1:2 |
Paraguay