| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | ||||
| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | ||||
| 9. Jornada | 12.09.2010 | Bolívar | - | Club San José | 0:0 |  |
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| 12. Jornada | 03.10.2010 | Club San José | - | Universitario de Sucre | 2:1 | ||||
| 14. Jornada | 10.10.2010 | Club San José | - | Jorge Wilstermann | 2:0 | ||||
| 15. Jornada | 17.10.2010 | The Strongest | - | Club San José | 1:2 |  |
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| 13. Jornada | 28.10.2010 | Blooming | - | Club San José | 2:2 |  |
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| 18. Jornada | 31.10.2010 | Club San José | - | Oriente Petrolero | 0:3 | |
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| 17. Jornada | 04.11.2010 | Real Potosí | - | Club San José | 1:3 | |
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| 20. Jornada | 14.11.2010 | Club San José | - | Bolívar | 0:1 | ||||
| 21. Jornada | 21.11.2010 | Real Mamoré | - | Club San José | 3:0 | |
Paraguay