| 26. Jornada | 05.08.2021 | El Nacional | - | Atlético Santo Domingo | 3:2 | ||||
| 27. Jornada | 12.08.2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 | ||||
| 28. Jornada | 18.08.2021 | Atlético Santo Domingo | - | Chacaritas FC | 0:0 |  |
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| 30. Jornada | 01.09.2021 | Atlético Santo Domingo | - | Cumbayá | 2:1 | ||||
| 31. Jornada | 08.09.2021 | América de Quito | - | Atlético Santo Domingo | 1:1 | ||||
| 32. Jornada | 15.09.2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:0 | ||||
| 33. Jornada | 22.09.2021 | Liga de Portoviejo | - | Atlético Santo Domingo | 3:3 | ||||
| 34. Jornada | 29.09.2021 | Atlético Santo Domingo | - | El Nacional | 1:1 | ||||
| 35. Jornada | 06.10.2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 |  |
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| 36. Jornada | 13.10.2021 | Gualaceo SC | - | Atlético Santo Domingo | 1:0 |
Argentina