| 1. Jornada | 24.01.2016 | River Plate | - | Cerro Porteño | 0:2 | ||||
| 2. Jornada | 29.01.2016 | Sol de América | - | River Plate | 0:1 |  |
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| 3. Jornada | 04.02.2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
| 4. Jornada | 09.02.2016 | Libertad | - | River Plate | 3:1 | ||||
| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | ||||
| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Jornada | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 |
Paraguay