| 2. Jornada | 01.08.2021 | FK Krasnodar | - | FK Khimki | 0:1 | ||||
| 3. Jornada | 08.08.2021 | FK Khimki | - | FK Rostov | 1:1 | ||||
| 4. Jornada | 16.08.2021 | FK Sochi | - | FK Khimki | 3:0 | ||||
| 6. Jornada | 27.08.2021 | FK Khimki | - | FK Nizhny Novgorod | 1:1 | ||||
| 7. Jornada | 11.09.2021 | Spartak Moskva | - | FK Khimki | 3:1 |  |
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| 8. Jornada | 18.09.2021 | FK Ufa | - | FK Khimki | 3:2 | ||||
| 9. Jornada | 25.09.2021 | FK Khimki | - | Lokomotiv Moskva | 0:0 | |
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| 10. Jornada | 02.10.2021 | Arsenal Tula | - | FK Khimki | 0:0 | ||||
| 12. Jornada | 22.10.2021 | Dinamo Moskva | - | FK Khimki | 4:1 | ||||
| 13. Jornada | 31.10.2021 | FK Khimki | - | FK Ural | 0:0 | ||||
| 14. Jornada | 06.11.2021 | Krylia Sovetov | - | FK Khimki | 3:0 | ||||
| 18. Jornada | 12.12.2021 | Akhmat Grozny | - | FK Khimki | 4:1 |
Rusia