| 3. Jornada | 04.09.2021 | Royal Antwerp FC [Sub 18] | - | Cercle Brugge [Sub 18] | 1:0 |  |
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| 4. Jornada | 11.09.2021 | Royal Antwerp FC [Sub 18] | - | Standard Liège [Sub 18] | 1:2 | ||||
| 5. Jornada | 18.09.2021 | Oud-Heverlee Leuven [Sub 18] | - | Royal Antwerp FC [Sub 18] | 0:0 | ||||
| 6. Jornada | 25.09.2021 | Royal Antwerp FC [Sub 18] | - | Sint-Truidense VV [Sub 18] | 0:2 | ||||
| 7. Jornada | 02.10.2021 | KVC Westerlo [Sub 18] | - | Royal Antwerp FC [Sub 18] | 0:2 | ||||
| 9. Jornada | 16.10.2021 | KV Mechelen [Sub 18] | - | Royal Antwerp FC [Sub 18] | 1:0 | ||||
| 10. Jornada | 23.10.2021 | Royal Antwerp FC [Sub 18] | - | Club Brugge KV [Sub 18] | 0:2 | ||||
| 12. Jornada | 13.11.2021 | Royal Antwerp FC [Sub 18] | - | KAA Gent [Sub 18] | 4:1 |
Bélgica