| 1. Jornada | 18.04.2021 | Columbus Crew | - | Philadelphia Union | 0:0 | ||||
| 2. Jornada | 01.05.2021 | CF Montréal | - | Columbus Crew | 0:0 | ||||
| 2. Jornada | 08.05.2021 | Columbus Crew | - | D.C. United | 3:1 | ||||
| 2. Jornada | 17.05.2021 | New England Revolution | - | Columbus Crew | 1:0 | ||||
| 2. Jornada | 23.05.2021 | New York City FC | - | Columbus Crew | 1:2 |  |
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| 2. Jornada | 29.05.2021 | Columbus Crew | - | Toronto FC | 2:1 |
Brasil
Estados Unidos