| 1. Jornada | 25.07.2010 | Jaguares Chiapas | - | Club Necaxa | 1:1 |  |
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| 2. Jornada | 31.07.2010 | Club Necaxa | - | UANL Tigres | 0:2 | |
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| 3. Jornada | 08.08.2010 | Atlas Guadalajara | - | Club Necaxa | 0:1 | ||||
| 4. Jornada | 14.08.2010 | Club Necaxa | - | Gallos Blancos (old) | 1:1 | |
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| 5. Jornada | 22.08.2010 | Monarcas Morelia | - | Club Necaxa | 1:0 | ||||
| 6. Jornada | 29.08.2010 | CF América | - | Club Necaxa | 1:1 | ||||
| 7. Jornada | 11.09.2010 | Club Necaxa | - | Deportivo Toluca | 1:1 | ||||
| 8. Jornada | 19.09.2010 | Santos Laguna | - | Club Necaxa | 2:1 | ||||
| 9. Jornada | 25.09.2010 | Club Necaxa | - | Cruz Azul | 2:1 | |
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| 10. Jornada | 03.10.2010 | CF Monterrey | - | Club Necaxa | 2:1 | ||||
| 11. Jornada | 09.10.2010 | Club Necaxa | - | Puebla FC | 1:0 | ||||
| 12. Jornada | 17.10.2010 | Deportivo Guadalajara | - | Club Necaxa | 1:0 | ||||
| 13. Jornada | 23.10.2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
| 14. Jornada | 28.10.2010 | Estudiantes Tecos | - | Club Necaxa | 0:2 | |
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| 15. Jornada | 01.11.2010 | Club Necaxa | - | Atlante | 1:2 | |
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| 16. Jornada | 07.11.2010 | Pumas UNAM | - | Club Necaxa | 2:0 | ||||
| 17. Jornada | 13.11.2010 | Club Necaxa | - | CF Pachuca | 1:2 |
México