| 1. Jornada | 18.09.2021 | Club Tijuana [] | - | Pumas UNAM [] | 1:2 | ||||
| 2. Jornada | 25.09.2021 | Pumas UNAM [] | - | FC Juárez [] | 5:0 |  |
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| 4. Jornada | 09.10.2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 3. Jornada | 20.10.2021 | CF América [] | - | Pumas UNAM [] | 3:2 | ||||
| 6. Jornada | 23.10.2021 | Gallos Blancos [] | - | Pumas UNAM [] | 2:2 | ||||
| 7. Jornada | 30.10.2021 | Pumas UNAM [] | - | Cruz Azul [] | 2:2 | ||||
| 8. Jornada | 06.11.2021 | Deportivo Toluca [] | - | Pumas UNAM [] | 3:1 | |
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| 9. Jornada | 13.11.2021 | Pumas UNAM [] | - | Club Tijuana [] | 2:1 | |
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| 10. Jornada | 20.11.2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 | |
México