| 28. Jornada | 18.08.2021 | El Nacional | - | Guayaquil SC | 3:1 | ||||
| 33. Jornada | 22.09.2021 | Chacaritas FC | - | Guayaquil SC | 4:1 | ||||
| 34. Jornada | 01.10.2021 | Guayaquil SC | - | América de Quito | 1:0 | ||||
| 35. Jornada | 06.10.2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Jornada | 13.10.2021 | Guayaquil SC | - | Atlético Porteño | 4:3 |  |
Ecuador