| 1. Jornada | 25.06.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Jornada | 02.07.2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 3. Jornada | 09.07.2022 | Santos Laguna [] | - | CF Monterrey [] | 3:5 | ||||
| 4. Jornada | 16.07.2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 | ||||
| 5. Jornada | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | ||||
| 7. Jornada | 06.08.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 2:2 |  |
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| 10. Jornada | 28.08.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 9. Jornada | 21.09.2022 | Club León [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Jornada | 08.10.2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 | ||||
| 17. Jornada | 15.10.2022 | CF Monterrey [] | - | Santos Laguna [] | 1:1 |
México