| 4. Jornada | 22.02.2021 | Club Nacional | - | Libertad | 0:3 | ||||
| 2. Jornada | 24.02.2021 | Guaireña FC | - | Libertad | 1:0 |  |
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| 10. Jornada | 04.04.2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Jornada | 12.04.2021 | Libertad | - | Guaireña FC | 2:1 |  |
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| 12. Jornada | 18.04.2021 | Cerro Porteño | - | Libertad | 0:3 | |
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| 13. Jornada | 26.04.2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 |  |
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| 15. Jornada | 09.05.2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 | ||||
| 16. Jornada | 17.05.2021 | Guaraní | - | Libertad | 1:6 | |
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| 17. Jornada | 22.05.2021 | Libertad | - | Sol de América | 1:2 | ||||
| 18. Jornada | 29.05.2021 | Sportivo Luqueño | - | Libertad | 1:3 |
Uruguay