| 16. Jornada | 16.01.2022 | Sestao River | - | CD Izarra | 0:0 | ||||
| 18. Jornada | 22.01.2022 | CD Laredo | - | Sestao River | 0:1 |  |
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| 19. Jornada | 30.01.2022 | Sestao River | - | Real Sociedad C | 1:0 | ||||
| 20. Jornada | 05.02.2022 | AD San Juan | - | Sestao River | 0:2 |  |
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| 23. Jornada | 27.02.2022 | Sestao River | - | Racing Rioja CF | 2:0 | ||||
| 27. Jornada | 27.03.2022 | Sestao River | - | Rayo Cantabria | 0:0 | ||||
| 28. Jornada | 03.04.2022 | Sestao River | - | Náxara CD | 2:0 | |
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| 29. Jornada | 09.04.2022 | Osasuna B | - | Sestao River | 1:1 | ||||
| 30. Jornada | 16.04.2022 | Sestao River | - | SD Gernika | 3:2 | |
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| 31. Jornada | 24.04.2022 | UD Logroñés Promesas | - | Sestao River | 1:1 | ||||
| 32. Jornada | 30.04.2022 | Sestao River | - | UD Mutilvera | 3:0 | ||||
| 33. Jornada | 08.05.2022 | CD Izarra | - | Sestao River | 0:1 | |
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| 34. Jornada | 15.05.2022 | Sestao River | - | CD Tropezón | 4:2 | |
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