| 4. Jornada | 14.08.2021 | FK Rostov | - | CSKA Moscú | 1:3 | ||||
| 5. Jornada | 22.08.2021 | FK Nizhny Novgorod | - | FK Rostov | 1:2 |  |
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| 6. Jornada | 27.08.2021 | FK Ural | - | FK Rostov | 1:1 | ||||
| 7. Jornada | 13.09.2021 | FK Rostov | - | FK Krasnodar | 1:1 | ||||
| 8. Jornada | 18.09.2021 | Krylia Sovetov | - | FK Rostov | 4:2 | ||||
| 9. Jornada | 26.09.2021 | FK Rostov | - | Akhmat Grozny | 1:2 | ||||
| 10. Jornada | 03.10.2021 | Lokomotiv Moskva | - | FK Rostov | 1:2 | ||||
| 11. Jornada | 16.10.2021 | FK Sochi | - | FK Rostov | 3:2 |  |
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| 12. Jornada | 23.10.2021 | FK Rostov | - | Arsenal Tula | 4:0 | |
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| 13. Jornada | 30.10.2021 | Spartak Moskva | - | FK Rostov | 1:1 | ||||
| 14. Jornada | 07.11.2021 | FK Rostov | - | Rubin Kazan | 5:1 | |
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| 16. Jornada | 27.11.2021 | Akhmat Grozny | - | FK Rostov | 2:0 | ||||
| 17. Jornada | 03.12.2021 | Zenit | - | FK Rostov | 2:2 | ||||
| 18. Jornada | 11.12.2021 | FK Rostov | - | FK Ural | 1:4 |
Angola