| 3. Jornada | 24.07.2022 | ART Municipal Jalapa | - | UNAN Managua | 3:3 |  |
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| 5. Jornada | 08.08.2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 3:1 |  |
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| 6. Jornada | 11.08.2022 | Diriangén FC | - | ART Municipal Jalapa | 0:0 | ||||
| 7. Jornada | 14.08.2022 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 0:3 | |
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| 8. Jornada | 22.08.2022 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | |
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| 4. Jornada | 25.08.2022 | Managua FC | - | ART Municipal Jalapa | 1:1 | |
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| 9. Jornada | 28.08.2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 10. Jornada | 05.09.2022 | ART Municipal Jalapa | - | Real Estelí FC | 0:0 | ||||
| 11. Jornada | 11.09.2022 | ART Municipal Jalapa | - | Matagalpa FC | 2:1 | ||||
| 12. Jornada | 06.10.2022 | UNAN Managua | - | ART Municipal Jalapa | 2:2 | |
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| 14. Jornada | 27.10.2022 | ART Municipal Jalapa | - | CD Walter Ferretti | 1:0 | ||||
| 15. Jornada | 30.10.2022 | ART Municipal Jalapa | - | Diriangén FC | 1:2 | |
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| 16. Jornada | 13.11.2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:3 | ||||
| 17. Jornada | 21.11.2022 | ART Municipal Jalapa | - | Juventus Managua | 2:0 | |
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| 18. Jornada | 30.11.2022 | H&H Export Sébaco | - | ART Municipal Jalapa | 1:0 | |
Uruguay