| 5. Jornada | 13.02.2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Jornada | 20.02.2016 | Club Nacional | - | River Plate | 0:0 |  |
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| 7. Jornada | 27.02.2016 | River Plate | - | Guaraní | 1:1 | |
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| 8. Jornada | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 | |
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| 9. Jornada | 05.03.2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 10. Jornada | 11.03.2016 | General Díaz | - | River Plate | 3:0 | |
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| 11. Jornada | 21.03.2016 | River Plate | - | Club Olimpia | 0:3 | |
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| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | |
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| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 | |
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| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Jornada | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | |
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| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Jornada | 01.05.2016 | Guaraní | - | River Plate | 4:2 | ||||
| 19. Jornada | 06.05.2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Jornada | 08.05.2016 | Club Rubio Ñu | - | River Plate | 1:2 | ||||
| 21. Jornada | 14.05.2016 | River Plate | - | General Díaz | 1:1 | |
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| 22. Jornada | 22.05.2016 | Club Olimpia | - | River Plate | 3:0 | |
Paraguay