| 1. Jornada | 17.04.2021 | Houston Dynamo | - | San Jose Earthquakes | 2:1 | ||||
| 1. Jornada | 25.04.2021 | Portland Timbers | - | Houston Dynamo | 2:1 | ||||
| 2. Jornada | 01.05.2021 | Houston Dynamo | - | Los Angeles FC | 1:1 | ||||
| 2. Jornada | 08.05.2021 | FC Dallas | - | Houston Dynamo | 1:1 | ||||
| 2. Jornada | 13.05.2021 | Houston Dynamo | - | Sporting Kansas City | 1:0 | ||||
| 2. Jornada | 16.05.2021 | Colorado Rapids | - | Houston Dynamo | 3:1 | ||||
| 2. Jornada | 23.05.2021 | Houston Dynamo | - | Vancouver Whitecaps | 2:1 |  |
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| 2. Jornada | 30.05.2021 | Sporting Kansas City | - | Houston Dynamo | 3:2 | |
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| 3. Jornada | 24.06.2021 | Houston Dynamo | - | Portland Timbers | 2:2 | ||||
| 3. Jornada | 27.06.2021 | Real Salt Lake | - | Houston Dynamo | 1:1 | ||||
| 4. Jornada | 04.07.2021 | Houston Dynamo | - | FC Cincinnati | 1:1 | |
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| 5. Jornada | 05.08.2021 | Austin FC | - | Houston Dynamo | 3:2 | ||||
| 5. Jornada | 19.08.2021 | Real Salt Lake | - | Houston Dynamo | 2:1 | ||||
| 5. Jornada | 29.08.2021 | Houston Dynamo | - | Minnesota United FC | 1:2 | ||||
| 6. Jornada | 16.09.2021 | Los Angeles Galaxy | - | Houston Dynamo | 1:1 | |
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| 7. Jornada | 31.10.2021 | Houston Dynamo | - | Colorado Rapids | 0:1 |
Honduras