| 1. Jornada | 29.08.2021 | CD Badajoz | - | CF Talavera | 2:0 | ||||
| 2. Jornada | 03.09.2021 | CF Talavera | - | UD SS Reyes | 2:0 | ||||
| 3. Jornada | 11.09.2021 | Real Racing | - | CF Talavera | 5:1 | ||||
| 4. Jornada | 19.09.2021 | CF Talavera | - | CD Calahorra | 0:0 | ||||
| 5. Jornada | 26.09.2021 | SD Logroñés | - | CF Talavera | 3:2 | ||||
| 6. Jornada | 03.10.2021 | CF Talavera | - | Extremadura UD | 1:1 | ||||
| 7. Jornada | 09.10.2021 | CyD Leonesa | - | CF Talavera | 1:2 | ||||
| 8. Jornada | 17.10.2021 | CF Talavera | - | Unionistas CF | 1:1 | ||||
| 9. Jornada | 23.10.2021 | UD Logroñés | - | CF Talavera | 1:0 | ||||
| 10. Jornada | 29.10.2021 | CF Talavera | - | Valladolid B | 0:2 | ||||
| 11. Jornada | 06.11.2021 | CD Tudelano | - | CF Talavera | 0:2 |  |
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| 12. Jornada | 14.11.2021 | CF Talavera | - | Racing de Ferrol | 1:2 | ||||
| 13. Jornada | 21.11.2021 | Bilbao Athletic | - | CF Talavera | 0:1 | |
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| 14. Jornada | 28.11.2021 | CF Talavera | - | Rayo Majadahonda | 0:0 | ||||
| 15. Jornada | 04.12.2021 | CF Talavera | - | Inter de Madrid | 1:1 | ||||
| 16. Jornada | 12.12.2021 | Celta B | - | CF Talavera | 2:0 | |
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| 17. Jornada | 19.12.2021 | CF Talavera | - | Real Unión | 1:3 | |
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| 18. Jornada | 09.01.2022 | Deportivo | - | CF Talavera | 1:0 | |
España