| 1. Jornada | 07.01.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:5 | ||||
| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | ||||
| 5. Jornada | 12.02.2022 | Santos Laguna [Sub 20] | - | CF América [Sub 20] | 0:0 | ||||
| 2. Jornada | 16.02.2022 | Mazatlán FC [Sub 20] | - | CF América [Sub 20] | 2:1 |  |
|||
| 6. Jornada | 20.02.2022 | CF América [Sub 20] | - | CF Pachuca [Sub 20] | 1:2 |  |
|||
| 7. Jornada | 26.02.2022 | Pumas UNAM [Sub 20] | - | CF América [Sub 20] | 0:1 | ||||
| 8. Jornada | 01.03.2022 | CF América [Sub 20] | - | Gallos Blancos [Sub 20] | 2:0 | ||||
| 9. Jornada | 05.03.2022 | CF Monterrey [Sub 20] | - | CF América [Sub 20] | 3:2 | |
|||
| 10. Jornada | 12.03.2022 | Deportivo Guadalajara [Sub 20] | - | CF América [Sub 20] | 0:2 | ||||
| 11. Jornada | 20.03.2022 | CF América [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:0 |
México