| 1. Jornada | 09.01.2022 | Cruz Azul | - | Club Tijuana | 2:0 | ||||
| 2. Jornada | 16.01.2022 | Club Tijuana | - | Club León | 1:1 |  |
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| 3. Jornada | 29.01.2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
| 4. Jornada | 06.02.2022 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
| 5. Jornada | 12.02.2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 6. Jornada | 19.02.2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Jornada | 26.02.2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 | ||||
| 8. Jornada | 02.03.2022 | Deportivo Toluca | - | Club Tijuana | 1:2 | ||||
| 10. Jornada | 14.03.2022 | Santos Laguna | - | Club Tijuana | 4:0 | ||||
| 11. Jornada | 21.03.2022 | Club Tijuana | - | FC Juárez | 1:0 | |
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| 12. Jornada | 04.04.2022 | UANL Tigres | - | Club Tijuana | 2:0 | ||||
| 9. Jornada | 07.04.2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 13. Jornada | 12.04.2022 | CF Pachuca | - | Club Tijuana | 0:0 | ||||
| 14. Jornada | 16.04.2022 | Club Tijuana | - | CF América | 1:3 | |
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| 15. Jornada | 20.04.2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 16. Jornada | 25.04.2022 | Club Tijuana | - | Gallos Blancos | 2:2 | |
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| 17. Jornada | 01.05.2022 | CF Monterrey | - | Club Tijuana | 2:0 |
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