| 1. Jornada | 18.04.2021 | D.C. United | - | New York City FC | 2:1 |  |
|||
| 1. Jornada | 25.04.2021 | New England Revolution | - | D.C. United | 1:0 |  |
|||
| 2. Jornada | 02.05.2021 | San Jose Earthquakes | - | D.C. United | 4:1 | ||||
| 2. Jornada | 14.05.2021 | D.C. United | - | Chicago Fire | 1:0 | |
|||
| 2. Jornada | 17.05.2021 | D.C. United | - | Orlando City | 0:1 | |
|||
| 2. Jornada | 24.05.2021 | D.C. United | - | Philadelphia Union | 0:1 | ||||
| 2. Jornada | 30.05.2021 | Inter Miami CF | - | D.C. United | 0:3 | |
|||
| 3. Jornada | 20.06.2021 | D.C. United | - | Inter Miami CF | 1:0 | ||||
| 3. Jornada | 24.06.2021 | CF Montréal | - | D.C. United | 0:0 | ||||
| 3. Jornada | 28.06.2021 | New York City FC | - | D.C. United | 2:1 | ||||
| 4. Jornada | 03.07.2021 | D.C. United | - | Toronto FC | 7:1 | ||||
| 7. Jornada | 28.10.2021 | D.C. United | - | New York RB | 1:0 | ||||
| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Estados Unidos