| 1. Jornada | 23.07.2017 | Lobos BUAP | - | Santos Laguna | 2:2 | ||||
| 2. Jornada | 31.07.2017 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
| 4. Jornada | 14.08.2017 | Santos Laguna | - | CD Veracruz | 2:3 |  |
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| 5. Jornada | 19.08.2017 | Club Tijuana | - | Santos Laguna | 2:0 | ||||
| 6. Jornada | 24.08.2017 | Santos Laguna | - | Deportivo Guadalajara | 1:1 |  |
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| 7. Jornada | 27.08.2017 | Club León | - | Santos Laguna | 1:2 | ||||
| 12. Jornada | 02.10.2017 | Santos Laguna | - | Puebla FC | 0:0 | ||||
| 13. Jornada | 16.10.2017 | Santos Laguna | - | Atlas Guadalajara | 0:1 | ||||
| 10. Jornada | 19.10.2017 | Santos Laguna | - | Club Necaxa | 3:2 | ||||
| 14. Jornada | 22.10.2017 | Gallos Blancos | - | Santos Laguna | 1:2 | ||||
| 15. Jornada | 30.10.2017 | Santos Laguna | - | CF Pachuca | 2:2 | |
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| 16. Jornada | 05.11.2017 | Pumas UNAM | - | Santos Laguna | 2:2 | ||||
| 11. Jornada | 10.11.2017 | CF Monterrey | - | Santos Laguna | 1:1 | |
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| 17. Jornada | 20.11.2017 | Santos Laguna | - | CF América | 0:1 |
Uruguay
