| 2. Jornada | 14.01.2018 | UANL Tigres | - | Santos Laguna | 2:1 |  |
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| 3. Jornada | 22.01.2018 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 4. Jornada | 29.01.2018 | CD Veracruz | - | Santos Laguna | 1:1 | ||||
| 5. Jornada | 04.02.2018 | Santos Laguna | - | Club Tijuana | 0:0 | ||||
| 6. Jornada | 11.02.2018 | Deportivo Guadalajara | - | Santos Laguna | 0:2 | ||||
| 7. Jornada | 15.02.2018 | Santos Laguna | - | Club León | 5:1 | ||||
| 8. Jornada | 18.02.2018 | Deportivo Toluca | - | Santos Laguna | 2:0 | |
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| 9. Jornada | 26.02.2018 | Santos Laguna | - | Cruz Azul | 2:0 | |
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| 10. Jornada | 04.03.2018 | Club Necaxa | - | Santos Laguna | 1:2 | ||||
| 11. Jornada | 12.03.2018 | Santos Laguna | - | CF Monterrey | 3:2 | ||||
| 12. Jornada | 17.03.2018 | Puebla FC | - | Santos Laguna | 0:1 | ||||
| 13. Jornada | 31.03.2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
| 14. Jornada | 09.04.2018 | Santos Laguna | - | Gallos Blancos | 3:0 | ||||
| 15. Jornada | 15.04.2018 | CF Pachuca | - | Santos Laguna | 3:1 | |
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| 16. Jornada | 23.04.2018 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 17. Jornada | 29.04.2018 | CF América | - | Santos Laguna | 1:0 |
Uruguay
