| 1. Jornada | 23.07.2018 | Santos Laguna | - | Lobos BUAP | 2:1 |  |
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| 2. Jornada | 28.07.2018 | Monarcas Morelia | - | Santos Laguna | 3:1 | ||||
| 3. Jornada | 06.08.2018 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 4. Jornada | 13.08.2018 | Deportivo Guadalajara | - | Santos Laguna | 1:2 | ||||
| 5. Jornada | 20.08.2018 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 6. Jornada | 23.08.2018 | Club Tijuana | - | Santos Laguna | 2:2 | |
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| 7. Jornada | 27.08.2018 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
| 8. Jornada | 02.09.2018 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 9. Jornada | 16.09.2018 | Santos Laguna | - | Club León | 3:0 | |
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| 10. Jornada | 24.09.2018 | Santos Laguna | - | CD Veracruz | 1:1 | ||||
| 11. Jornada | 30.09.2018 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 12. Jornada | 06.10.2018 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 13. Jornada | 21.10.2018 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
| 14. Jornada | 27.10.2018 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 15. Jornada | 04.11.2018 | Gallos Blancos | - | Santos Laguna | 2:1 | ||||
| 16. Jornada | 12.11.2018 | Santos Laguna | - | CF América | 1:1 | ||||
| 17. Jornada | 25.11.2018 | Pumas UNAM | - | Santos Laguna | 1:1 |
Uruguay
