| 1. Jornada | 06.01.2019 | Lobos BUAP | - | Santos Laguna | 2:0 | ||||
| 2. Jornada | 14.01.2019 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
| 3. Jornada | 19.01.2019 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 4. Jornada | 28.01.2019 | Santos Laguna | - | Deportivo Guadalajara | 1:0 | ||||
| 5. Jornada | 03.02.2019 | UANL Tigres | - | Santos Laguna | 2:1 | ||||
| 6. Jornada | 11.02.2019 | Santos Laguna | - | Club Tijuana | 1:1 | ||||
| 7. Jornada | 17.02.2019 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 8. Jornada | 25.02.2019 | Santos Laguna | - | Deportivo Toluca | 4:0 | ||||
| 9. Jornada | 03.03.2019 | Club León | - | Santos Laguna | 3:0 |  |
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| 10. Jornada | 09.03.2019 | CD Veracruz | - | Santos Laguna | 2:2 | |
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| 11. Jornada | 18.03.2019 | Santos Laguna | - | Club Necaxa | 1:2 | ||||
| 12. Jornada | 30.03.2019 | Atlas Guadalajara | - | Santos Laguna | 1:0 | ||||
| 13. Jornada | 08.04.2019 | Santos Laguna | - | CF Pachuca | 0:0 | ||||
| 14. Jornada | 15.04.2019 | CF Monterrey | - | Santos Laguna | 4:0 | ||||
| 15. Jornada | 22.04.2019 | Santos Laguna | - | Gallos Blancos | 2:1 | ||||
| 16. Jornada | 28.04.2019 | CF América | - | Santos Laguna | 1:0 | ||||
| 17. Jornada | 06.05.2019 | Santos Laguna | - | Pumas UNAM | 5:2 | |
Uruguay
