| 1. Jornada | 22.07.2019 | Santos Laguna | - | Deportivo Guadalajara | 3:0 |  |
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| 2. Jornada | 29.07.2019 | Santos Laguna | - | FC Juárez | 3:0 | |
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| 3. Jornada | 03.08.2019 | Atlas Guadalajara | - | Santos Laguna | 1:2 | |
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| 4. Jornada | 12.08.2019 | Santos Laguna | - | Puebla FC | 4:1 | ||||
| 5. Jornada | 19.08.2019 | Club Necaxa | - | Santos Laguna | 3:0 | |
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| 6. Jornada | 24.08.2019 | Santos Laguna | - | CF Monterrey | 2:1 | |
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| 7. Jornada | 29.08.2019 | Club León | - | Santos Laguna | 2:2 | ||||
| 9. Jornada | 16.09.2019 | Santos Laguna | - | CF Pachuca | 2:2 | ||||
| 10. Jornada | 22.09.2019 | Atlético San Luis | - | Santos Laguna | 2:3 | |
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| 11. Jornada | 26.09.2019 | Santos Laguna | - | CD Veracruz | 5:0 | |
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| 12. Jornada | 29.09.2019 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 13. Jornada | 06.10.2019 | UANL Tigres | - | Santos Laguna | 4:0 | ||||
| 14. Jornada | 19.10.2019 | Santos Laguna | - | Club Tijuana | 4:1 | |
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| 15. Jornada | 26.10.2019 | Monarcas Morelia | - | Santos Laguna | 2:2 | ||||
| 16. Jornada | 30.10.2019 | Santos Laguna | - | Gallos Blancos | 1:0 | ||||
| 17. Jornada | 03.11.2019 | CF América | - | Santos Laguna | 1:2 | |
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| 18. Jornada | 11.11.2019 | Santos Laguna | - | Cruz Azul | 3:1 | |
Uruguay
