| 2. Jornada | 12.03.2022 | FK Senica | - | MFK Zemplín Michalovce | 2:1 | ||||
| 4. Jornada | 02.04.2022 | MFK Zemplín Michalovce | - | FK Pohronie | 1:0 |  |
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| 5. Jornada | 08.04.2022 | Tatran Liptovský Mikuláš | - | MFK Zemplín Michalovce | 3:1 | ||||
| 7. Jornada | 23.04.2022 | MFK Zemplín Michalovce | - | FK Senica | 1:0 | ||||
| 8. Jornada | 30.04.2022 | FK Pohronie | - | MFK Zemplín Michalovce | 1:2 | ||||
| 9. Jornada | 13.05.2022 | MFK Zemplín Michalovce | - | Tatran Liptovský Mikuláš | 1:2 |
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