| 1. Jornada | 26.02.2022 | Los Angeles FC | - | Colorado Rapids | 3:0 | ||||
| 2. Jornada | 07.03.2022 | Los Angeles FC | - | Portland Timbers | 1:1 | ||||
| 2. Jornada | 12.03.2022 | Inter Miami CF | - | Los Angeles FC | 0:2 | ||||
| 2. Jornada | 21.03.2022 | Los Angeles FC | - | Vancouver Whitecaps | 3:1 | ||||
| 3. Jornada | 03.04.2022 | Orlando City | - | Los Angeles FC | 2:4 |  |
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| 3. Jornada | 10.04.2022 | Los Angeles Galaxy | - | Los Angeles FC | 2:1 | ||||
| 4. Jornada | 19.05.2022 | Los Angeles FC | - | Austin FC | 1:2 | ||||
| 4. Jornada | 21.05.2022 | Columbus Crew | - | Los Angeles FC | 0:2 | ||||
| 4. Jornada | 29.05.2022 | Los Angeles FC | - | San Jose Earthquakes | 3:2 | |
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| 5. Jornada | 26.06.2022 | Los Angeles FC | - | New York RB | 2:0 | ||||
| 6. Jornada | 30.07.2022 | Los Angeles FC | - | Seattle Sounders | 2:1 | ||||
| 7. Jornada | 07.08.2022 | Real Salt Lake | - | Los Angeles FC | 1:4 | ||||
| 7. Jornada | 14.08.2022 | Los Angeles FC | - | Charlotte FC | 5:0 | ||||
| 7. Jornada | 17.08.2022 | Los Angeles FC | - | D.C. United | 1:0 |
Uruguay
