| 3. Jornada | 19.07.2022 | CF Pachuca | - | Mazatlán FC | 1:1 | ||||
| 4. Jornada | 23.07.2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Jornada | 28.07.2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 6. Jornada | 31.07.2022 | Club Tijuana | - | Mazatlán FC | 2:0 | ||||
| 7. Jornada | 06.08.2022 | Mazatlán FC | - | Deportivo Guadalajara | 2:1 |  |
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| 8. Jornada | 14.08.2022 | Club León | - | Mazatlán FC | 0:3 | ||||
| 9. Jornada | 17.08.2022 | Mazatlán FC | - | Gallos Blancos | 1:1 | ||||
| 10. Jornada | 21.08.2022 | FC Juárez | - | Mazatlán FC | 1:1 | ||||
| 11. Jornada | 27.08.2022 | Mazatlán FC | - | CF América | 1:3 | ||||
| 12. Jornada | 04.09.2022 | CF Monterrey | - | Mazatlán FC | 0:0 | |
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| 13. Jornada | 08.09.2022 | Mazatlán FC | - | Atlas Guadalajara | 1:0 | |
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| 14. Jornada | 11.09.2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 15. Jornada | 17.09.2022 | Mazatlán FC | - | Deportivo Toluca | 1:1 | ||||
| 16. Jornada | 24.09.2022 | Club Necaxa | - | Mazatlán FC | 2:2 | ||||
| 17. Jornada | 03.10.2022 | Santos Laguna | - | Mazatlán FC | 3:0 |
México