| 12. Jornada | 01.04.2022 | Atlético San Luis [Sub 18] | - | Mazatlán FC [Sub 18] | 3:1 | ||||
| 15. Jornada | 20.04.2022 | Atlético San Luis [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | ||||
| 16. Jornada | 24.04.2022 | Cruz Azul [Sub 18] | - | Atlético San Luis [Sub 18] | 2:1 | ||||
| 17. Jornada | 01.05.2022 | Atlético San Luis [Sub 18] | - | Santos Laguna [Sub 18] | 0:1 |  |
México