| 1. Jornada | 24.01.2016 | Club Nacional | - | Guaraní | 2:1 | ||||
| 3. Jornada | 04.02.2016 | Club Nacional | - | Club Olimpia | 2:2 | ||||
| 4. Jornada | 08.02.2016 | Sol de América | - | Club Nacional | 4:3 | ||||
| 6. Jornada | 20.02.2016 | Club Nacional | - | River Plate | 0:0 | ||||
| 7. Jornada | 27.02.2016 | Deportivo Capiatá | - | Club Nacional | 2:4 |  |
|||
| 8. Jornada | 03.03.2016 | Club Nacional | - | General Díaz | 1:3 | ||||
| 9. Jornada | 06.03.2016 | Cerro Porteño | - | Club Nacional | 1:2 | ||||
| 10. Jornada | 12.03.2016 | Club Nacional | - | Sportivo Luqueño | 1:1 | ||||
| 11. Jornada | 20.03.2016 | General Caballero ZC | - | Club Nacional | 1:3 | |
|||
| 16. Jornada | 21.04.2016 | Libertad | - | Club Nacional | 4:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Jornada | 30.04.2016 | Club Nacional | - | Deportivo Capiatá | 0:1 | ||||
| 19. Jornada | 05.05.2016 | General Díaz | - | Club Nacional | 1:1 | ||||
| 20. Jornada | 09.05.2016 | Club Nacional | - | Cerro Porteño | 1:1 |
Brasil