| 1. Jornada | 08.01.2022 | Pumas UNAM [] | - | Cruz Azul [] | 2:1 | ||||
| 3. Jornada | 22.01.2022 | Pumas UNAM [] | - | FC Juárez [] | 2:1 | ||||
| 2. Jornada | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 5. Jornada | 05.02.2022 | Pumas UNAM [] | - | CF Pachuca [] | 4:3 | ||||
| 6. Jornada | 12.02.2022 | Gallos Blancos [] | - | Pumas UNAM [] | 1:3 | ||||
| 7. Jornada | 19.02.2022 | Puebla FC [] | - | Pumas UNAM [] | 0:4 | ||||
| 9. Jornada | 05.03.2022 | Pumas UNAM [] | - | Club Necaxa [] | 1:1 | ||||
| 10. Jornada | 16.03.2022 | FC Juárez [] | - | Pumas UNAM [] | 1:1 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 15. Jornada | 23.03.2022 | Cruz Azul [] | - | Pumas UNAM [] | 1:4 |  |
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| 12. Jornada | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | ||||
| 14. Jornada | 30.03.2022 | Pumas UNAM [] | - | Gallos Blancos [] | 2:1 | ||||
| 16. Jornada | 23.04.2022 | Pumas UNAM [] | - | Deportivo Toluca [] | 3:1 | ||||
| 17. Jornada | 30.04.2022 | Club Necaxa [] | - | Pumas UNAM [] | 0:0 | ||||
| 18. Jornada | 07.05.2022 | Pumas UNAM [] | - | Puebla FC [] | 2:1 |
México