| 5. Jornada | 20.02.2022 | UNAN Managua | - | CD Walter Ferretti | 2:2 | ||||
| 8. Jornada | 07.03.2022 | CD Walter Ferretti | - | Real Estelí FC | 2:3 | ||||
| 13. Jornada | 08.04.2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:1 | ||||
| 14. Jornada | 11.04.2022 | CD Walter Ferretti | - | UNAN Managua | 4:1 | ||||
| 15. Jornada | 14.04.2022 | CD Walter Ferretti | - | Juventus Managua | 2:1 | ||||
| 16. Jornada | 24.04.2022 | H&H Export Sébaco | - | CD Walter Ferretti | 2:0 | ||||
| 17. Jornada | 28.04.2022 | Real Estelí FC | - | CD Walter Ferretti | 0:0 | ||||
| 18. Jornada | 02.05.2022 | CD Walter Ferretti | - | Managua FC | 1:0 |  |
Nicaragua