| 1. Jornada | 25.04.2021 | Los Angeles FC | - | Seattle Sounders | 1:1 | ||||
| 2. Jornada | 01.05.2021 | Houston Dynamo | - | Los Angeles FC | 1:1 | ||||
| 3. Jornada | 20.06.2021 | Los Angeles FC | - | Houston Dynamo | 1:1 | ||||
| 3. Jornada | 26.06.2021 | Sporting Kansas City | - | Los Angeles FC | 2:1 | ||||
| 4. Jornada | 18.07.2021 | Los Angeles FC | - | Real Salt Lake | 2:1 | ||||
| 4. Jornada | 22.07.2021 | Portland Timbers | - | Los Angeles FC | 2:1 | ||||
| 5. Jornada | 05.08.2021 | Los Angeles FC | - | Sporting Kansas City | 1:4 |  |
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| 6. Jornada | 04.09.2021 | Los Angeles FC | - | Sporting Kansas City | 4:0 | |
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| 6. Jornada | 13.09.2021 | Los Angeles FC | - | Real Salt Lake | 3:2 | |
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| 6. Jornada | 16.09.2021 | Austin FC | - | Los Angeles FC | 1:2 | ||||
| 6. Jornada | 20.09.2021 | Portland Timbers | - | Los Angeles FC | 2:1 | ||||
| 6. Jornada | 26.09.2021 | San Jose Earthquakes | - | Los Angeles FC | 2:0 | ||||
| 6. Jornada | 30.09.2021 | Los Angeles FC | - | Portland Timbers | 1:2 | ||||
| 7. Jornada | 21.10.2021 | FC Dallas | - | Los Angeles FC | 2:3 | ||||
| 7. Jornada | 24.10.2021 | Minnesota United FC | - | Los Angeles FC | 1:1 |
Estados Unidos