| 3. Jornada | 18.08.2021 | FK Renova | - | FK Borec | 2:0 | ||||
| 4. Jornada | 22.08.2021 | FK Borec | - | FK Bregalnica Štip | 1:1 | ||||
| 5. Jornada | 28.08.2021 | Makedonija GP | - | FK Borec | 3:2 |  |
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| 14. Jornada | 21.11.2021 | FK Borec | - | FK Renova | 1:4 | |
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| 18. Jornada | 12.12.2021 | FK Borec | - | KF Shkupi | 0:3 | |
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| 19. Jornada | 13.02.2022 | FK Skopje | - | FK Borec | 1:1 | ||||
| 21. Jornada | 27.02.2022 | FK Borec | - | FC Struga | 0:1 | ||||
| 22. Jornada | 09.03.2022 | FK AP Brera Strumica | - | FK Borec | 5:0 | ||||
| 23. Jornada | 13.03.2022 | FK Bregalnica Štip | - | FK Borec | 3:0 | ||||
| 25. Jornada | 03.04.2022 | KF Shkëndija 79 | - | FK Borec | 0:0 | ||||
| 29. Jornada | 23.04.2022 | GFK Tikvesh | - | FK Borec | 5:0 | |
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| 31. Jornada | 04.05.2022 | FK Rabotnički | - | FK Borec | 2:1 | ||||
| 32. Jornada | 08.05.2022 | FK Pelister | - | FK Borec | 2:1 | ||||
| 33. Jornada | 15.05.2022 | FK Borec | - | FK Renova | 1:5 |
Macedonia del Norte