| 3. Jornada | 22.01.2022 | UANL Tigres [] | - | Santos Laguna [] | 2:1 |  |
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| 5. Jornada | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | ||||
| 9. Jornada | 05.03.2022 | Atlético San Luis [] | - | UANL Tigres [] | 0:2 | ||||
| 12. Jornada | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 18. Jornada | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
México