| 1. Jornada | 15.08.2021 | Southampton Sub-21 | - | Norwich City Sub-21 | 0:3 |  |
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| 5. Jornada | 19.09.2021 | Southampton Sub-21 | - | Burnley FC U23 | 0:2 | |
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| 6. Jornada | 27.09.2021 | Birmingham City U23 | - | Southampton Sub-21 | 3:2 |  |
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| 8. Jornada | 18.10.2021 | Wolverhampton Wanderers Sub-21 | - | Southampton Sub-21 | 0:1 | ||||
| 9. Jornada | 25.10.2021 | Reading Sub-21 | - | Southampton Sub-21 | 0:1 | |
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| 10. Jornada | 31.10.2021 | Southampton Sub-21 | - | Aston Villa Sub-21 | 4:0 | |
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| 12. Jornada | 21.11.2021 | Sunderland Sub-21 | - | Southampton Sub-21 | 3:2 | |
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| 13. Jornada | 28.11.2021 | Southampton Sub-21 | - | West Bromwich Albion Sub-21 | 3:1 | ||||
| 14. Jornada | 06.12.2021 | Stoke City Sub-21 | - | Southampton Sub-21 | 3:0 |
Inglaterra