| 3. Jornada | 23.05.2010 | Houston Dynamo | - | D.C. United | 2:0 | ||||
| 4. Jornada | 03.06.2010 | New York RB | - | Houston Dynamo | 2:1 | ||||
| 4. Jornada | 06.06.2010 | Los Angeles Galaxy | - | Houston Dynamo | 4:1 |  |
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| 5. Jornada | 02.07.2010 | Toronto FC | - | Houston Dynamo | 1:1 | ||||
| 5. Jornada | 11.07.2010 | Houston Dynamo | - | Columbus Crew | 0:0 | ||||
| 5. Jornada | 25.07.2010 | Columbus Crew | - | Houston Dynamo | 3:0 | ||||
| 6. Jornada | 15.08.2010 | New England Revolution | - | Houston Dynamo | 1:0 | ||||
| 6. Jornada | 29.08.2010 | Colorado Rapids | - | Houston Dynamo | 3:0 | ||||
| 7. Jornada | 06.09.2010 | Houston Dynamo | - | San Jose Earthquakes | 1:2 | ||||
| 7. Jornada | 23.09.2010 | Kansas City Wizards | - | Houston Dynamo | 4:3 | |
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| 8. Jornada | 02.10.2010 | Philadelphia Union | - | Houston Dynamo | 1:1 | ||||
| 8. Jornada | 11.10.2010 | Houston Dynamo | - | New England Revolution | 1:2 |  |
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| 8. Jornada | 17.10.2010 | San Jose Earthquakes | - | Houston Dynamo | 0:1 | ||||
| 8. Jornada | 23.10.2010 | Houston Dynamo | - | Seattle Sounders | 2:1 | |
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Estados Unidos