| 1. Jornada | 09.01.2023 | Santos Laguna | - | UANL Tigres | 0:3 | ||||
| 2. Jornada | 15.01.2023 | Santos Laguna | - | Pumas UNAM | 3:0 | ||||
| 3. Jornada | 21.01.2023 | Mazatlán FC | - | Santos Laguna | 1:2 |  |
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| 4. Jornada | 27.01.2023 | Atlas Guadalajara | - | Santos Laguna | 2:2 | ||||
| 5. Jornada | 05.02.2023 | Santos Laguna | - | CF América | 2:2 | ||||
| 6. Jornada | 12.02.2023 | FC Juárez | - | Santos Laguna | 3:1 | ||||
| 8. Jornada | 19.02.2023 | Atlético San Luis | - | Santos Laguna | 1:1 | ||||
| 7. Jornada | 24.02.2023 | Santos Laguna | - | Deportivo Toluca | 0:5 | ||||
| 9. Jornada | 27.02.2023 | Santos Laguna | - | Puebla FC | 3:2 | ||||
| 10. Jornada | 05.03.2023 | Deportivo Guadalajara | - | Santos Laguna | 2:0 | ||||
| 11. Jornada | 13.03.2023 | Santos Laguna | - | Club Tijuana | 3:2 | ||||
| 12. Jornada | 20.03.2023 | Club León | - | Santos Laguna | 4:1 | ||||
| 13. Jornada | 01.04.2023 | Club Necaxa | - | Santos Laguna | 0:0 | ||||
| 14. Jornada | 10.04.2023 | Santos Laguna | - | CF Pachuca | 1:4 | ||||
| 15. Jornada | 17.04.2023 | CF Monterrey | - | Santos Laguna | 1:2 | ||||
| 16. Jornada | 24.04.2023 | Santos Laguna | - | Gallos Blancos | 0:2 |
México