| 1. Jornada | 12.01.2025 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 2. Jornada | 21.01.2025 | CF Pachuca | - | Santos Laguna | 2:1 | ||||
| 3. Jornada | 26.01.2025 | Santos Laguna | - | CF América | 1:4 | ||||
| 4. Jornada | 30.01.2025 | FC Juárez | - | Santos Laguna | 1:0 | ||||
| 5. Jornada | 03.02.2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Jornada | 08.02.2025 | Club Necaxa | - | Santos Laguna | 3:2 | ||||
| 7. Jornada | 15.02.2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 9. Jornada | 20.02.2025 | Santos Laguna | - | Cruz Azul | 0:1 | ||||
| 8. Jornada | 24.02.2025 | Santos Laguna | - | Atlas Guadalajara | 2:0 | ||||
| 10. Jornada | 03.03.2025 | CF Monterrey | - | Santos Laguna | 4:2 | ||||
| 11. Jornada | 10.03.2025 | Santos Laguna | - | Club León | 2:1 | ||||
| 12. Jornada | 16.03.2025 | UANL Tigres | - | Santos Laguna | 3:0 | ||||
| 13. Jornada | 31.03.2025 | Santos Laguna | - | Atlético San Luis | 2:3 | ||||
| 14. Jornada | 07.04.2025 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 15. Jornada | 14.04.2025 | Santos Laguna | - | Gallos Blancos | 1:2 | ||||
| 16. Jornada | 17.04.2025 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 17. Jornada | 21.04.2025 | Santos Laguna | - | Club Tijuana | 0:4 |
México