| 1. Jornada | 22.01.2022 | CD Walter Ferretti | - | Real Madriz | 3:0 | ||||
| 2. Jornada | 06.02.2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:0 | ||||
| 3. Jornada | 10.02.2022 | CD Walter Ferretti | - | Diriangén FC | 2:3 | ||||
| 4. Jornada | 14.02.2022 | ART Municipal Jalapa | - | CD Walter Ferretti | 3:2 |  |
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| 6. Jornada | 27.02.2022 | CD Walter Ferretti | - | H&H Export Sébaco | 5:0 | |
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| 7. Jornada | 04.03.2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | ||||
| 8. Jornada | 07.03.2022 | CD Walter Ferretti | - | Real Estelí FC | 2:3 |  |
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| 12. Jornada | 03.04.2022 | Diriangén FC | - | CD Walter Ferretti | 1:1 | ||||
| 13. Jornada | 08.04.2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:1 | |
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| 16. Jornada | 24.04.2022 | H&H Export Sébaco | - | CD Walter Ferretti | 2:0 | |
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| 18. Jornada | 02.05.2022 | CD Walter Ferretti | - | Managua FC | 1:0 |
México