| 2. Jornada | 14.02.2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
| 4. Jornada | 26.02.2022 | Club Nacional | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 5. Jornada | 04.03.2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 7. Jornada | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Jornada | 04.04.2022 | Club Nacional | - | Sportivo Ameliano | 2:1 |  |
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| 9. Jornada | 09.04.2022 | Club Olimpia | - | Club Nacional | 1:2 | |
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| 10. Jornada | 17.04.2022 | Guaraní | - | Club Nacional | 0:1 | ||||
| 11. Jornada | 21.04.2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
| 12. Jornada | 26.04.2022 | Club Nacional | - | Sol de América | 0:3 | ||||
| 13. Jornada | 01.05.2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
| 14. Jornada | 07.05.2022 | Club Nacional | - | Resistencia SC | 1:2 | ||||
| 15. Jornada | 10.05.2022 | 12 de Octubre de Itauguá | - | Club Nacional | 1:2 | |
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| 16. Jornada | 14.05.2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
| 18. Jornada | 13.06.2022 | Club Nacional | - | Tacuary | 3:0 | ||||
| 19. Jornada | 19.06.2022 | Sportivo Ameliano | - | Club Nacional | 2:2 | |
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| 22. Jornada | 01.07.2022 | Guaireña FC | - | Club Nacional | 1:1 |
Paraguay