| 1. Jornada | 19.09.2021 | Mazatlán FC [] | - | Club León [] | 2:2 | ||||
| 2. Jornada | 25.09.2021 | Club León [] | - | UANL Tigres [] | 2:1 | ||||
| 4. Jornada | 09.10.2021 | Deportivo Guadalajara [] | - | Club León [] | 3:0 | ||||
| 5. Jornada | 16.10.2021 | Club León [] | - | Mazatlán FC [] | 4:2 |  |
|||
| 6. Jornada | 23.10.2021 | Atlas Guadalajara [] | - | Club León [] | 2:0 | ||||
| 7. Jornada | 30.10.2021 | Club León [] | - | Atlético San Luis [] | 2:0 | ||||
| 9. Jornada | 13.11.2021 | CF Monterrey [] | - | Club León [] | 2:2 |
México