| 3. Jornada | 08.09.2018 | Santos Laguna [Sub 20] | - | Puebla FC [Sub 20] | 2:3 | ||||
| 9. Jornada | 14.09.2018 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 3:4 | ||||
| 1. Jornada | 19.09.2018 | Santos Laguna [Sub 20] | - | Lobos BUAP [Sub 20] | 2:0 | ||||
| 2. Jornada | 10.10.2018 | Monarcas Morelia [Sub 20] | - | Santos Laguna [Sub 20] | 2:0 | ||||
| 13. Jornada | 20.10.2018 | CF Pachuca [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 14. Jornada | 26.10.2018 | Santos Laguna [Sub 20] | - | CF Monterrey [Sub 20] | 0:2 |  |
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| 15. Jornada | 04.11.2018 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 1:2 | ||||
| 17. Jornada | 25.11.2018 | Pumas UNAM [Sub 20] | - | Santos Laguna [Sub 20] | 4:0 |
México